Fromer Members of Agency 355

I just browsed here recently on Sick Burn, and I saw that Jake mentioned they were descendants of the former team of Agency 355. There was Jennings, and he teamed up with Sacajawea, Sam Wilson, and Davey Crockett. I can't be sure how Jake, Alex, or even Diana are related to them. The show didn't explain much before the cancellation. It kind of boggles the mind, so what do you think? What's the connection with these guys?